The defence, which was exploited by Anthony Calvillo (404 yards passing), will be missing linebacker Otis Floyd. The former Lion will be sidelined for a second straight contest with a concussion.
B.C. released Floyd earlier this year, one of several off-season moves by the Lions, who enter Friday's tilt last in the four-team West with a 1-3 mark.
Dealt a 48-10 loss at Calgary last week, they look nothing like the powerhouse outfit of the past few years, but Buono has yet to reach panic mode.
"I've gone through this a million times," said Buono, who is four wins shy of surpassing the all-time CFL record of 228. "This isn't the first time we've been 1-3. Teams I direct haven't been this way, but it's not a big deal."
Of greater concern is finding a way to get quarterbacks Buck Pierce and backup Jarious Jackson back on their game. Pierce completed just eight of 16 passes for 97 yards and an interception versus Calgary and has already taken a number of hits this season, resulting in four fumbles.
Jackson hit on only two of eight attempts against the Stampeders for six yards and a pickoff, but might be the better choice for playing time in Hamilton.
B.C. has taken nine of the past 10 meetings against the Ticats and is 45-28-3 in the series all-time.
But this time the Lions will be missing injured kick-returner Ian Smart, who twisted a knee at Monday's practice. For Hamilton, running back Terry Caulley was added to the 46-man active roster.